SW033291 | 15-PGDH inhibitor | Probechem Biochemicals

Chemical Structure : SW033291

CAS No.: 459147-39-8

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SW033291 (SW-033291)

货号: PC-45107Not For Human Use, Lab Use Only.

SW033291 (SW-033291) is a potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

SW033291 (SW-033291) is a potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM.
SW033291 increases PGE2 levels by 3.5-fold at 500 nM, with EC50 of 75 nM.
SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues, accelerates hematopoietic recovery in mice receiving a bone marrow transplant.
SW033291 also promotes tissue regeneration in mouse models of colon and liver injury.

物理化学性质&存储条件

分子量	412.5913
分子式	C21H20N2OS3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thieno[2,3-b]pyridin-3-amine, 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)-

参考文献

1. Zhang Y, et al. Science. 2015 Jun 12;348(6240):aaa2340.

2. Antczak MI, et al. J Med Chem. 2017 May 11;60(9):3979-4001.

SW033291 (SW-033291)

生物&药学活性

物理化学性质&存储条件

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SW033291 (SW-033291)

生物&药学活性

物理化学性质&存储条件

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