SW016789 | VDAC1 activator | Probechem Biochemicals

Chemical Structure : SW016789

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SW016789 (SW 016789)

货号: PC-23747Not For Human Use, Lab Use Only.

SW016789 is a small molecule that acutely and chronically alters beta cell secretory responses, targets and activates VDAC1 to enhance Ca2+ influx and insulin release.

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生物&药学活性

SW016789 is a small molecule that acutely and chronically alters beta cell secretory responses, targets and activates VDAC1 to enhance Ca2+ influx and insulin release.
SW016789 also impaires glucose-stimulated insulin secretion (GSIS) in solated human islets, does not impact cell viability, cell death, or the live/dead cell ratio.
SW016789 treatment potentiated nutrient- but not KCl-stimulated Ca2+ influx.
SW016789 does not impact oxygen consumption rate or canonical glycolysis and tricarboxylic acid (TCA) cycle metabolites in MIN6 beta cells.
SW016789 acutely synergizes with activators of protein kinase C and voltage-dependent calcium channels (VDCCs) to induce secretion.
SW016789 reduced the abundance of ER-associated degradation (ERAD).

物理化学性质&存储条件

分子量	349.45
分子式	C20H19N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-benzyl-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethan-1-ol

参考文献

1. Rodrigues-Dos-Santos K, et al. Endocrinology. 2022 Jul 1;163(7):bqac081.

2. Roy G, et al. bioRxiv [Preprint]. 2024 Dec 26:2024.12.26.629558.

SW016789 (SW 016789)

生物&药学活性

物理化学性质&存储条件

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SW016789 (SW 016789)

生物&药学活性

物理化学性质&存储条件

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