SUVN-911 | α4β2 antagonist | Probechem Biochemicals

Chemical Structure : SUVN-911

CAS No.: 2414674-71-6

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SUVN-911 (SUVN911)

货号: PC-72169Not For Human Use, Lab Use Only.

SUVN-911 (Ropanicant) is a novel, potent, selective, orally active α4β2 nAChR receptor antagonist with Ki of 1.5 nM.

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10 mg	￥3780	In stock
50 mg	￥7580	In stock
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生物&药学活性

SUVN-911 (Ropanicant) is a novel, potent, selective, orally active α4β2 nAChR receptor antagonist with Ki of 1.5 nM.
SUVN-911 dispalys negligible binding affinity toward the ganglionic α3β4 receptor apart from showing selectivity over 70 other targets.
SUVN-911 is orally bioavailable and showed good brain penetration in rats.
SUVN-911 demonstrated significant antidepressant activity and dose-dependent receptor occupancy in rats, does not affect the locomotor activity at doses several folds higher than its efficacy dose and is devoid of cardiovascular and gastrointestinal side effects,
SUVN-911 shows potential therapeutic utility in the treatment of depression.

物理化学性质&存储条件

分子量	261.146
分子式	C11H14Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Azabicyclo[3.1.0]hexane, 3-[[(6-chloro-3-pyridinyl)oxy]methyl]-, hydrochloride (1:1), (1R,3S,5R)-

参考文献

1. Ramakrishna Nirogi, et al. J Med Chem. 2020 Mar 26;63(6):2833-2853.

SUVN-911 (SUVN911)

生物&药学活性

物理化学性质&存储条件

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SUVN-911 (SUVN911)

生物&药学活性

物理化学性质&存储条件

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