SUN11602 | bFGF mimic | Probechem Biochemicals

Chemical Structure : SUN11602

CAS No.: 704869-38-5

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SUN11602 (SUN-11602, SUN 11602)

货号: PC-42401Not For Human Use, Lab Use Only.

A novel aniline compound that mimics the neuroprotective effects of bFGF by activating FGFR1-MEK/ERK signaling pathway.

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10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2680	In stock
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生物&药学活性

SUN11602 is an aniline compound that mimics the neuroprotective effects of bFGF by activating FGFR1-MEK/ERK signaling pathway.
SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons, augments phosphorylation of FGFR-1 and ERK-1/2, increases the levels of CALB1 gene expression.
SUN11602 increases the levels of newly synthesized calcium-binding protein calbindin-D28k (Calb) in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca(2+) in WT mice.
SUN11602 attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer's disease.

物理化学性质&存储条件

分子量	451.60428
分子式	C26H37N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 37 mg/mL
Chemical Name/SMILES	Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-

参考文献

1. Murayama N, et al. ACS Chem Neurosci. 2013 Feb 20;4(2):266-76.

2. Ogino R, et al. Brain Res. 2014 Oct 17;1585:159-66.

3. Murayama N, et al. Brain Res. 2015 Jan 12;1594:71-81.

SUN11602 (SUN-11602, SUN 11602)

生物&药学活性

物理化学性质&存储条件

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SUN11602 (SUN-11602, SUN 11602)

生物&药学活性

物理化学性质&存储条件

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