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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-SU 5402
SU 5402

Chemical Structure : SU 5402

CAS No.: 215543-92-3

SU 5402 (SU-5402;SU5402)

货号: PC-42567Not For Human Use, Lab Use Only.

A selective FGFR1 inhibitor with IC50 of 10-20 uM.

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10 mg ¥800 In stock
50 mg ¥2800 In stock
100 mg ¥4960 In stock

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A selective FGFR1 inhibitor with IC50 of 10-20 uM; does not inhibit tyrosine phosphorylation of PDGFR and EGFR (IC50>200 uM), weakly inhibits insulin receptor; specifically inhibits the growth of the t(4;14)-positive MM lines, KMS-11 and OPM-2, reduces cell viability and increases apoptosis.

物理化学性质&存储条件

分子量 296.3205
分子式 C17H16N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

1H-Pyrrole-3-propanoic acid, 2-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-

参考文献

1. Mohammadi M, et al. Science. 1997 May 9;276(5314):955-60.

2. Udayakumar TS, et al. Int J Cancer. 2001 Jan 15;91(2):187-92.

3. Hoffman MP, et al. Development. 2002 Dec;129(24):5767-78.

4. Grand EK, et al. Leukemia. 2004 May;18(5):962-6.

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