SU4312 | VEGFR2/PDGFR inhibitor | Probechem Biochemicals

Chemical Structure : SU4312

CAS No.: 5812-07-7

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SU4312 (NSC 86429, SU 4312)

货号: PC-61860Not For Human Use, Lab Use Only.

SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively.

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10 mg	￥1280	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively.
SU 4312 displays no significant inhibitory activity against EGFR, HER2, and IGF-1R (>100 uM).
SU 4312 exhibits neuroprotection against MPP(+) at least partly via selective and direct inhibition of nNOS.
SU 4312 inhibits VEGF-dependent angiogenesis in a zebrafish assay (IC50=1.8 uM) without affecting normal cells.

物理化学性质&存储条件

分子量	264.3
分子式	C17H16N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one

参考文献

1. Sun L, et al. J Med Chem. 1998 Jul 2;41(14):2588-603.

2. Tran TC, et al. Cancer Res. 2007 Dec 1;67(23):11386-92.

3. Cui W, et al. Br J Pharmacol. 2013 Mar;168(5):1201-14.

SU4312 (NSC 86429, SU 4312)

生物&药学活性

物理化学性质&存储条件

参考文献

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SU4312 (NSC 86429, SU 4312)

生物&药学活性

物理化学性质&存储条件

参考文献

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