Halicin (SU3327) | JNK inhibitor | Probechem Biochemicals

Chemical Structure : SU3327

CAS No.: 40045-50-9

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SU3327 (Halicin)

货号: PC-27751Not For Human Use, Lab Use Only.

Halicin (SU3327) is a potent, selective and substrate competitive c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 0.7 uM, inhibits TNF-α stimulated phosphorylation of c-Jun with IC50 of 6.23 uM in HeLa cells.

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10 mg	￥880	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Halicin (SU3327) is a potent, selective and substrate competitive c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 0.7 uM, inhibits TNF-α stimulated phosphorylation of c-Jun with IC50 of 6.23 uM in HeLa cells.
Halicin (SU3327) shows an IC50 of 239 nM in displacing pepJIP1, as measured by a DELFIA assay.
Halicin (SU3327) is 142 fold less active against p38α, and completely inactive against Akt kinase, metalloprotease LF (lethal factor) and the proprotein convertase furin.
Halicin (SU3327) improves cardiac function and reduces heart damage during IR.

物理化学性质&存储条件

分子量	261.29
分子式	C5H3N5O2S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-Nitrothiazol-2-yl)thio)-1,3,4-thiadiazol-2-amine

参考文献

1. De SK, et al. J Med Chem. 2009 Apr 9;52(7):1943-52.

2. Augustine C, et al. Neuroscience. 2014 Aug 22;274:1-10.

3. Jang S, et al. PLoS One. 2014 Nov 25;9(11):e113526.

SU3327 (Halicin)

生物&药学活性

物理化学性质&存储条件

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SU3327 (Halicin)

生物&药学活性

物理化学性质&存储条件

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