SU 16f |CAS:251356-45-3 Probechem Biochemicals

Chemical Structure : SU 16f

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SU 16f (SU16f)

货号: PC-62329Not For Human Use, Lab Use Only.

SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively.

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生物&药学活性

SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively; inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 =0.11 uM).

物理化学性质&存储条件

分子量	386.451
分子式	C24H22N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

参考文献

1. Cao N, et al. Science. 2016 Jun 3;352(6290):1216-20.

2. Andersen RK, et al. Stem Cell Res Ther. 2015 Oct 8;6:196.

3. Lee E, et al. Sci Rep. 2014 Jul 28;4:5853.

SU 16f (SU16f)

生物&药学活性

物理化学性质&存储条件

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SU 16f (SU16f)

生物&药学活性

物理化学性质&存储条件

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