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首页-小分子抑制剂&激动剂-NF-κB Pathway-IκB kinase (IKK)-SU1261
SU1261

Chemical Structure : SU1261

CAS No.: 3061890-98-7

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SU1261 (SU 1261)

货号: PC-22934Not For Human Use, Lab Use Only.

SU1261 is a potent, selective inhibitor of IKKα with Ki of 10 nM, >60-fold selective over IKKβ.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SU1261 is a potent, selective inhibitor of IKKα with Ki of 10 nM, >60-fold selective over IKKβ, selectively perturbs non-canonical NF-κB signalling whilst avoiding any significant impact upon the IKKβ-mediated canonical NF-κB pathway in cells.

物理化学性质&存储条件

分子量 431.50
分子式 C27H21N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(2-(3-(benzyloxy)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-indazol-3-amine

参考文献

1. Christopher Riley, et al. Molecules. 2024 Jul 26;29(15):3515.

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