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首页-小分子抑制剂&激动剂-Tyrosine Kinase-c-Met (HGFR)-SU11274
SU11274

Chemical Structure : SU11274

CAS No.: 658084-23-2

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SU11274 (SU 11274, PKI-SU11274, SU-11274)

货号: PC-42829Not For Human Use, Lab Use Only.

SU11274 (PKI-SU11274) is a potent, selective, ATP-competitive c-Met kinase inhibitor with IC50 of 20 nM, >50-fold selectivity over Bcr-Abl, JAK2, PDGFβR.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SU11274 (PKI-SU11274) is a potent, selective, ATP-competitive c-Met kinase inhibitor with IC50 of 20 nM, >50-fold selectivity over Bcr-Abl, JAK2, PDGFβR.
SU11274 (PKI-SU11274) induces G(1) cell cycle arrest and apoptosis with increased Annexin V staining and caspase 3 activity, specifically regulates cell growth in TPR-MET-transformed BaF3 cells with IC50 of <3 uM.
SU11274 (PKI-SU11274) differentially affects the kinase activity and subsequent signaling of various mutant forms of Met (M1268T and H1112Y).

物理化学性质&存储条件

分子量 568.0869
分子式 C28H30ClN5O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-

参考文献

1. Sattler M, et al. Cancer Res. 2003 Sep 1;63(17):5462-9.

2. Berthou S, et al. Oncogene. 2004 Jul 8;23(31):5387-93.

3. Ma PC, et al. Cancer Res. 2005 Feb 15;65(4):1479-88.

4. Jagadeeswaran R, et al. Cancer Res. 2006 Jan 1;66(1):352-61.

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