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首页-小分子抑制剂&激动剂-Others-Other Targets-SU056
SU056

Chemical Structure : SU056

CAS No.: 2376580-08-2

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SU056 (SU-056)

货号: PC-72492Not For Human Use, Lab Use Only.

SU056 (SU-056) is a specific small molecule that potently inhibits tumor growth and progression via Y box binding protein 1 (YBX1, YB1) inhibition.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SU056 (SU-056) is a specific small molecule that potently inhibits tumor growth and progression via Y box binding protein 1 (YBX1, YB1) inhibition.
SU056 inhibits cell proliferation, resistance to apoptosis in ovarian cancer (OC) cells, and arrests in the G1 phase.
SU056 (1-10 uM) strongly inhibits YB-1 expression, SU056 broadly inhibits YB-1 across different OC cell lines with IC50 of 5.6, 3.2, 3.7 uM against OVCAR4, OVCAR8, and SKOV3 cells.
SU056 treatment leads to enrichment of proteins associated with apoptosis and RNA degradation pathways while downregulating spliceosome pathway.
SU056 independently restrains OC progression and exerts a synergistic effect with paclitaxel to further reduce disease progression with no observable liver toxicity.
SU056 showed delayed disease progression via inhibition of drug efflux and multidrug resistance 1, and significantly lower neurotoxicity as compared with etoposide.

物理化学性质&存储条件

分子量 369.348
分子式 C20H16FNO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9-(3-Fluorophenyl)-6,9-dihydro-5-(2-hydroxyethyl)-1,3-dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

参考文献

1. Dhanir Tailor, et al. Cell Chem Biol. 2021 Aug 19;28(8):1206-1220.e6.

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