SU0547

Chemical Structure : SU0547

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货号: PC-23997Not For Human Use, Lab Use Only.

SU0547 is a specific small-molecule activator of DNA repair enzyme SMUG1 (Single-Strand-Selective Monofunctional Uraci-DNA Glycosylase 1) with AC50 of 4.3 uM, activates SMUG1 by more than 40-fold in vitro.

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生物&药学活性

SU0547 is a specific small-molecule activator of DNA repair enzyme SMUG1 (Single-Strand-Selective Monofunctional Uraci-DNA Glycosylase 1) with AC50 of 4.3 uM, activates SMUG1 by more than 40-fold in vitro.
SU0547 activates SMUG1 by as much as 350% at 100 nM in vitro.
SU0547 exhibits minimal inhibition on Src family (Src, Lck, Abl, Csk, and Yes1) and clinically relevant kinases (EGFR, HER2, BRAF, RET, and FLT3).
SU0547 (3-5 uM) significantly reduces the cytotoxicity of 5-hmdU and decreases levels of double-strand breaks induced by the damaged nucleoside.
SU0547 is a useful tool to study the mechanisms of 5-hmdU toxicity and the potentially beneficial effects of suppressing damage to pyrimidines in cellular DNA.

物理化学性质&存储条件

分子量	562.67
分子式	C34H34N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methoxy-6-(3-morpholinopropoxy)-N-(4-phenoxyphenyl)-2-phenylquinazolin-4-amine

参考文献

1. Gao Y, et al. DNA Repair (Amst). 2025 Jan 14;146:103809.

SU0547

生物&药学活性

物理化学性质&存储条件

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SU0547

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