SU0268 | OGG1 inhibitor | Probechem Biochemicals

Chemical Structure : SU0268

CAS No.: 2210228-45-6

加入收藏

SU0268 (SU 0268)

货号: PC-72024Not For Human Use, Lab Use Only.

SU0268 (SU 0268) is a potent, selective, noncovalent inhibitor DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) with IC50 of 59 nM.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg	￥5480	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SU0268 (SU 0268) is a potent, selective, noncovalent inhibitor DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) with IC50 of 59 nM.
SU0268 displays low or negligible inhibition against other repair enzymes MTH1, dUTPase, NUDT16, hABH2, hABH3, SMUG1 at 20 uM.
SU0268 shows good membrane permeability and no cytotoxicity in HEK293T and HeLa cells at active concentrations and demonstrates activity in inhibiting the enzyme in human cell lines.
SU0268 is a potentially useful tool in studies of the role of OGG1 in multiple disease-related pathways.

物理化学性质&存储条件

分子量	475.563
分子式	C26H25N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4'-(N-(1-(Cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide

参考文献

1. Yu-Ki Tahara, et al. J Am Chem Soc. 2018 Feb 14;140(6):2105-2114.

2. Qin S, et al. J Immunol. 2020 Oct 15;205(8):2231-2242.

3. Zhang L, et al. Redox Biol. 2021 Apr;40:101848.

SU0268 (SU 0268)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SU0268 (SU 0268)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.