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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA-PK-SU-11752
SU-11752

Chemical Structure : SU-11752

CAS No.: 688036-19-3

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SU-11752 (SU11752)

货号: PC-61970Not For Human Use, Lab Use Only.

SU-11752 is a potent, selective inhibitor of DNA-PK, >500-fold selectivity over PI3Kγ, inhibits DNA double-strand break repair in cells and sensitizs ionizing radiation in cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SU-11752 is a potent, selective inhibitor of DNA-PK, >500-fold selectivity over PI3Kγ, inhibits DNA double-strand break repair in cells and sensitizs ionizing radiation in cancer cells.

    物理化学性质&存储条件

    分子量 493.57
    分子式 C26H27N3O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-[[1,2-Dihydro-2-oxo-5-[(phenylamino)sulfonyl]-3H-indol-3-ylidene]methyl]-2,4-diethyl-1H-pyrrole-3-propanoic acid

    参考文献

    1. Ismail IH, et al. Oncogene. 2004 Jan 29;23(4):873-82.

    2. Harnor SJ, et al. ChemMedChem. 2017 Jun 21;12(12):895-900.

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