STX3451 | Microtubule inhibitor | Probechem Biochemicals

Chemical Structure : STX3451

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STX3451 (STX-3451, STX 3451)

货号: PC-61251Not For Human Use, Lab Use Only.

STX3451 is a non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM.

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生物&药学活性

STX3451 is a non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM.
STX3451 induces apoptosis in human malignant peripheral nerve sheath tumour (MPNST) cell lines.
STX3451 inhibits both PI3 kinase and mTOR signalling pathways, selectively kills MPNST-derived cells, but also halts growth of other tumour-derived NF1 cell lines.

物理化学性质&存储条件

分子量	487.365
分子式	C19H23BrN2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-Bromo-4,5-dimethoxybenzyl)-7-methoxy-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

参考文献

1. Shen YC, et al. Br J Cancer. 2015 Oct 20;113(8):1158-67.

2. Dohle W, et al. ChemMedChem. 2014 Aug;9(8):1783-93.

STX3451 (STX-3451, STX 3451)

生物&药学活性

物理化学性质&存储条件

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STX3451 (STX-3451, STX 3451)

生物&药学活性

物理化学性质&存储条件

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