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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-STX140
STX140

Chemical Structure : STX140

CAS No.: 401600-86-0

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STX140 (STX-140)

货号: PC-28770Not For Human Use, Lab Use Only.

STX140 is an orally bioavailable anti-angiogenic microtubule disruptor, shows promising anticancer potency both in vitro and in vivo, causes apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

STX140 is an orally bioavailable anti-angiogenic microtubule disruptor, shows promising anticancer potency both in vitro and in vivo, causes apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.

物理化学性质&存储条件

分子量 460.56
分子式 C19H28N2O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Methoxyestradiol 3,17-O,O-bis-sulfamate

参考文献

1. Newman SP, et al. Clin Cancer Res. 2008 Jan 15;14(2):597-606.

2. Newman SP, et al. Cancer Res. 2006 Jan 1;66(1):324-30.

3. Newman SP, et al. Br J Cancer. 2007 Dec 17;97(12):1673-82.

4. Meyer-Losic F, et al. PLoS One. 2013 Dec 6;8(12):e80305.

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