STX-0119| STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : STX-0119

CAS No.: 851095-32-4

加入收藏

STX-0119 (STX0119)

货号: PC-49088Not For Human Use, Lab Use Only.

STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM.
STX-0119 selectively abrogates the DNA binding activity of STAT3 and suppressed the expression of STAT3-regulated oncoproteins such as c-myc and survivin in cancer cells.
STX-0119 (160 mg/kg sid, p.o.) effectively abrogated the growth of human lymphoma cells in a SCC-3 subcutaneous xenograft model without visible toxicity.
STX-0119 attenuates liver fibrosis by inactivating hepatic stellate cells in mice.

物理化学性质&存储条件

分子量	382.37
分子式	C22H14N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide

参考文献

1. Matsuno K, et al. ACS Med Chem Lett. 2010 Jul 13;1(8):371-5.

2. Ashizawa T, et al. Int J Oncol. 2013 Jul;43(1):219-27.

3. Choi S, et al. Biochem Biophys Res Commun. 2019 May 21;513(1):49-55.

STX-0119 (STX0119)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

STX-0119 (STX0119)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.