STS66 | NKCC1 inhibitor | Probechem Biochemicals

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Na-K-Cl Cotransporter (NKCC)-STS66

Chemical Structure : STS66

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STS66 (NKCC1 inhibitor STS66)

货号: PC-72596Not For Human Use, Lab Use Only.

STS66 is a novel BBB-penetrant Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, reduces brain damage in mice after ischemic stroke.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

STS66 is a novel BBB-penetrant Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, reduces brain damage in mice after ischemic stroke.
STS66 treatment completely blocked the ischemia-induced elevation of pNKCC1, which is superior to BMT and STS5.
STS66 showed efficacy against permanent focal ischemic brain injury with hypertension comorbidity.

物理化学性质&存储条件

分子量	431.474
分子式	C19H24F3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(Butylamino)-2-phenoxy-5-[(2,2,2-trifluoroethylamino)methyl]benzenesulfonamide

参考文献

1. Huachen Huang, et al. Stroke. 2019 Apr;50(4):1021-1025.

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STS66 (NKCC1 inhibitor STS66)

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物理化学性质&存储条件

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STS66 (NKCC1 inhibitor STS66)

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物理化学性质&存储条件

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