STOCK1S-14279 | SPAK (STK39) inhibitor | Probechem Biochemicals

Chemical Structure : STOCK1S-14279

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STOCK1S-14279 (Stock 1S-14279)

货号: PC-72594Not For Human Use, Lab Use Only.

STOCK1S-14279 (Stock 1S-14279) is a specific small-molecule SPAK kinase (STK39) inhibitor with IC50 of 0.26 uM, inhibits SPAK-regulated phosphorylation and activation of NCC and NKCC1.

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生物&药学活性

STOCK1S-14279 (Stock 1S-14279) is a specific small-molecule SPAK kinase (STK39) inhibitor with IC50 of 0.26 uM.
STOCK1S-14279 inhibits SPAK-regulated phosphorylation and activation of NCC and NKCC1.
STOCK1S-14279 demonstrated a dose-dependent inhibitory effect of phosphorylation of endogenous NCC (pThr53) in mpkDCT cells and of NKCC1 (pThr206) in MOVAS cells.
STOCK1S-14279 rapidly and markedly reduced NCC phosphorylation (pSer71) with total NCC reduction was observed in the kidneys after 30 minutes of drug administration (in the aorta of mice intraperitoneally injected with 20 mg/kg).

物理化学性质&存储条件

分子量	537.615
分子式	C23H13BrCl3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((1-bromonaphthalen-2-yl)oxy)-3-chlorophenyl)-3,5-dichloro-2-hydroxybenzamide

参考文献

1. Kikuchi E, et al. J Am Soc Nephrol. 2015 Jul; 26(7):1525-36.

STOCK1S-14279 (Stock 1S-14279)

生物&药学活性

物理化学性质&存储条件

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STOCK1S-14279 (Stock 1S-14279)

生物&药学活性

物理化学性质&存储条件

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