STL001 | FOXM1 inhibitor | Probechem Biochemicals

Chemical Structure : STL001

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STL001 (STL-001)

货号: PC-22337Not For Human Use, Lab Use Only.

STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines.

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生物&药学活性

STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines.
STL001 (1, 5, and 10 μM) resulting in a dose-dependent reduction of the cellular levels of FOXM1 protein in human solid tumor-derived cell lines with high FOXM1 expression levels, including ovarian cancer (OVCAR-8, ES-2), colorectal cancer (HCT-116, HCT-FET), esophageal cancer (FLO-1), hormone receptor-positive (TAM-R) and triple negative (HCC-1143) breast cancers, and prostate cancer (22Rv1, LNCaP).
STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation.
STL001-induced FOXM1 suppression sensitizes human cancers of different origin to a broad-spectrum of cancer therapies.

物理化学性质&存储条件

分子量	509.53
分子式	C27H23N7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-(4-morpholino-6-(phenylamino)-1,3,5-triazin-2-yl)-1H-pyrazol-3-yl)phenyl furan-2-carboxylate

参考文献

1. Raghuwanshi S, et al. Cell Death Discov. 2024 May 2;10(1):211.

STL001 (STL-001)

生物&药学活性

物理化学性质&存储条件

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STL001 (STL-001)

生物&药学活性

物理化学性质&存储条件

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