STK793590 | DJ-1/PARK7 inhibitor | Probechem Biochemicals

Chemical Structure : STK793590

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STK793590 (DJ-1 inhibitor 15)

货号: PC-38777Not For Human Use, Lab Use Only.

STK793590 (DJ-1/PARK7 inhibitor 15) is a potent inhibitor of the Parkinson's disease associated protein DJ-1/PARK7 with Kd/IC50 of 0.1/0.28 uM, respectively.

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生物&药学活性

STK793590 (DJ-1/PARK7 inhibitor 15) is a potent inhibitor of the Parkinson's disease associated protein DJ-1/PARK7 with Kd/IC50 of 0.1/0.28 uM, respectively.
DJ-1/PARK7 inhibitor 15 inactivates the critical Cys106 residue of human DJ-1.
DJ-1/PARK7 inhibitor 15 showed robust inhibitory properties in vitro and suggested inhibition of the proposed deglycase detoxifying activity of DJ-1 in cell-based assays.

物理化学性质&存储条件

分子量	269.275
分子式	C16H12FNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-fluoro-1-phenethylindoline-2,3-dione

参考文献

1. Shinya Tashiro, et al. ACS Chem Biol. 2018 Sep 21;13(9):2783-2793.

STK793590 (DJ-1 inhibitor 15)

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STK793590 (DJ-1 inhibitor 15)

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