STK17A/B inhibitor 9

Chemical Structure : STK17A/B inhibitor 9

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货号: PC-22555Not For Human Use, Lab Use Only.

STK17A/B inhibitor 9 is a potent and selective, orally active STK17A/B inhibitor with IC50 of 23 nM (STK17A/DRAK1).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

STK17A/B inhibitor 9 is a potent and selective, orally active STK17A/B inhibitor with IC50 of 23 nM (STK17A/DRAK1).
STK17A/B inhibitor 9 shows high potency against STK17B (DRAK2) with 98.5% inhibition at 1 uM concentration.
STK17A/B inhibitor 9 shows moderate off-target inhibition only for AAK1, MYLK4, and NEK3/5, very low inhibitory potency against CLK4 (IC50 > 10,000 nM).
STK17A/B inhibitor 9 (1-10 uM) dose-dependently decreases STK17A, decreases levels of phosphorylated-p53 Serine-20 and phosphorylated-ILK Serine-246 on HEK293 cells overexpressing STK17A.
STK17A/B inhibitor 9 has EC50 values around or below 1 μM in several AML cell lines.
STK17A/B inhibitor 9 shows good oral bioavailability for in vivo efficacy studies in several AML PDX mouse models.

物理化学性质&存储条件

分子量	453.55
分子式	C26H27N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-isopropyl-4-((4-(2-(pyrrolidin-1-yl)quinazolin-6-yl)pyrimidin-2-yl)amino)benzamide

参考文献

1. Sana Chaudhry, et al. ACS Med Chem Lett. 2024 May 20;15(6):945-949.