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STI1

Chemical Structure : STI1

CAS No.: 2452401-65-7

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STI1 (SQOR inhibitor STI1)

货号: PC-72641Not For Human Use, Lab Use Only.

STI1 (SQOR inhibitor STI1) is a potent, specific, competitive inhibitor of human sulfide:quinone oxidoreductase (SQOR) with IC50 of 29 nM.

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5 mg ￥2380 In stock
10 mg ￥3780 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

STI1 (SQOR inhibitor STI1) is a potent, specific, competitive inhibitor of human sulfide:quinone oxidoreductase (SQOR) with IC50 of 29 nM.
STI1 is a competitive inhibitor that binds with high selectivity to the coenzyme Q-binding pocket in SQOR, does not inhibit ETF:QO, complex I, complex II or complex III, DHODH (all IC50>300 uM).
STI1 exhibited very low cytotoxicity and attenuated the hypertrophic response of neonatal rat ventricular cardiomyocytes and H9c2 cells induced by neurohormonal stressors.
STI1 mitigated the development of cardiomegaly, pulmonary congestion, dilatation of the left ventricle, and cardiac fibrosis and decreased the pressure gradient across the aortic constriction in transverse aortic constriction (TAC) mice.
STI1 dramatically improved survival, preserved cardiac function, and prevented the progression to HFrEF by impeding the transition from compensated to decompensated left ventricle hypertrophy.

物理化学性质&存储条件

分子量 316.364
分子式 C19H16N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-aminophenyl)-6-methoxy-3'-methyl-[2,2'-bipyridine]-5-carbonitrile

参考文献

1. Jackson MR, et al. Cardiovasc Res. 2021 Jun 16:cvab206.

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