STF-62247 |CAS:315702-99-9 Probechem Biochemicals

Chemical Structure : STF-62247

CAS No.: 315702-99-9

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STF-62247 (STF62247;STF 62247)

货号: PC-42248Not For Human Use, Lab Use Only.

STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells.

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10 mg	￥780	In stock
25 mg	￥1180	In stock
50 mg	￥1880	In stock
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生物&药学活性

STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells.
STF-62247 induces cytotoxicity and reduces tumor growth in VHL-deficient cells in a HIF-independent manner, PI3K and Golgi trafficking are required as initial signals in STF-62247-induced autophagy.

物理化学性质&存储条件

分子量	267.3488
分子式	C15H13N3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	2-Thiazolamine, N-(3-methylphenyl)-4-(4-pyridinyl)-

参考文献

1. Turcotte S, et al. Cancer Cell. 2008 Jul 8;14(1):90-102.

2. Turcotte S, et al. Autophagy. 2008 Oct;4(7):944-6.

3. Chan DA, et al. Cell Cycle. 2008 Oct;7(19):2987-90.

4. Kozako T, et al. Oncotarget. 2018 Jun 12;9(45):27645-27655.

STF-62247 (STF62247;STF 62247)

生物&药学活性

物理化学性质&存储条件

参考文献

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STF-62247 (STF62247;STF 62247)

生物&药学活性

物理化学性质&存储条件

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