STF-118804 |CAS:894187-61-2 Probechem Biochemicals

Chemical Structure : STF-118804

CAS No.: 894187-61-2

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STF-118804 (STF118804)

货号: PC-43221Not For Human Use, Lab Use Only.

STF-118804 is a potent, highly specific NAMPT inhibitor, reduces the viability of most B-ALL cell lines with high potency in the low nanomolar range (MV411 cell IC50= 6 nM).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

STF-118804 (STF118804) is a potent, highly specific NAMPT inhibitor, reduces the viability of most B-ALL cell lines with high potency in the low nanomolar range (MV411 cell IC50= 6 nM).
STF-118804 induces leukemia cell apoptosis without antecedent cell cycle arrest, shows potency in various cancer cells including high selectivity for colon and prostate cell line in an NCI-60 cell line panel screen.
STF-118804 is highly efficacious in vivo and effectively depletes leukemia stem cells.

物理化学性质&存储条件

分子量	461.5328
分子式	C25H23N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Benzamide, 4-[5-methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)-

参考文献

1. Matheny CJ, et al. Chem Biol. 2013 Nov 21;20(11):1352-63.

2. Espindola-Netto JM, et al. Oncotarget. 2017 Jun 29;8(49):85054-85067.

3. Deng H, et al. Neurochem Res. 2016 Sep;41(9):2367-79.

STF-118804 (STF118804)

生物&药学活性

物理化学性质&存储条件

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STF-118804 (STF118804)

生物&药学活性

物理化学性质&存储条件

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