STAT5 inhibitor 17f |CAS:2111834-61-6 Probechem Biochemicals

Chemical Structure : STAT5 inhibitor 17f

CAS No.: 2111834-61-6

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STAT5 inhibitor 17f (STAT5-IN-17f)

货号: PC-61125Not For Human Use, Lab Use Only.

A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.

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5 mg	￥2780	In stock
10 mg	￥4680	In stock
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100 mg		Get quote

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生物&药学活性

STAT5 inhibitor 17f is a novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.
STAT5 inhibitor 17f inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5.
STAT5 inhibitor 17f inhibits KU812 and K562 cell growth with IC50 of 9 and 5 uM, respectively, demonstrates highly potent antileukemic effect with minimal effects on bone marrow stromal cells.

物理化学性质&存储条件

分子量	397.522
分子式	C26H27N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-((1H-Indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline

参考文献

1. Juen L, et al. J Med Chem. 2017 Jul 27;60(14):6119-6136.

STAT5 inhibitor 17f (STAT5-IN-17f)

生物&药学活性

物理化学性质&存储条件

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STAT5 inhibitor 17f (STAT5-IN-17f)

生物&药学活性

物理化学性质&存储条件

参考文献

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