STAT3 inhibitor N4

Chemical Structure : STAT3 inhibitor N4

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货号: PC-38627Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

STAT3 inhibitor N4 is a small molecule capable of inhibiting the STAT3 SH2 domain with IC50 of 0.57 uM, SPR KD of 1.04 uM, inhibits STAT3 dimerization and transcription in vitro and suppresses pancreatic cancer in vivo.
N4 suppresses STAT3 activation in pancreatic cancer cells, suppresses pancreatic cancer cell growth, migration, and induces apoptosis.
N4 (20 mg/kg, i.p.) suppresses pancreatic cancer growth, exhibits potent anti-metastatic activity in a pancreatic cancer liver metastasis mouse model, and prolongs survival of tumor-bearing mice.

物理化学性质&存储条件

分子量	465.553
分子式	C29H27N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4bS)-6-cyano-3-methoxy-4b,8,8-trimethyl-7-oxo-N-(quinolin-8-yl)-4b,7,8,8a,9,10-hexahydrophenanthrene-2-carboxamide

参考文献

1. Huang Chen, et al. Oncogene. 2021 Feb;40(8):1440-1457.