STAT3 inhibitor K116 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : STAT3 inhibitor K116

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STAT3 inhibitor K116 (STAT3 CCD inhibitor)

货号: PC-24431Not For Human Use, Lab Use Only.

K116 is a potent allosteric inhibitor specifically targeting the STAT3 coiled-coil domain (CCD), selectively inhibits the phosphorylation of p-Y705STAT3 in breast cancer cell lines.

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生物&药学活性

K116 is a potent allosteric inhibitor specifically targeting the STAT3 coiled-coil domain (CCD), selectively inhibits the phosphorylation of p-Y705STAT3 in breast cancer cell lines.
K116 selectively inhibited the proliferation of breast cancer cells.
K116 (20 μM) directly monitored STAT3 stabilization and engagement within MDA-MB-468 cells, without affecting STAT1, STAT5, and Akt1.
K116 induced apoptosis and inhibited migration as well as pY705STAT3 nuclear translocation and transcriptional activity of STAT3.
K116 (30 mg kg−1) markedly suppressed tumor growth and inhibited STAT3 activity in a 4T1 cell-derived murine breast cancer model.

物理化学性质&存储条件

分子量	276.31
分子式	C13H12N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-(1-(2,4-dihydroxyphenyl)ethylidene)thiophene-2-carbohydrazide

参考文献

1. Huang M, et al. RSC Med Chem. 2025 Mar 24. doi: 10.1039/d4md00926f.

STAT3 inhibitor K116 (STAT3 CCD inhibitor)

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物理化学性质&存储条件

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STAT3 inhibitor K116 (STAT3 CCD inhibitor)

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物理化学性质&存储条件

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