STARD7 inhibitor M4

Chemical Structure : STARD7 inhibitor M4

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货号: PC-28118Not For Human Use, Lab Use Only.

STARD7 inhibitor M4 is a small molecule inhibitor of lipid transfer protein STARD7, shows broad-spectrum anti-influenza virus activity with IC50 of <0.6 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

STARD7 inhibitor M4 is a small molecule inhibitor of lipid transfer protein STARD7, shows broad-spectrum anti-influenza virus activity with IC50 of <0.6 uM.
M4 potently inhibits influenza B/Yamagata/16/88 virus with an IC50 of 0.03 μM, and an attenuated highly pathogenic avian influenza H5N1 strain (A/Vietnam/1203/04 HALo), with an IC50 of 0.09 μM.
M4 is also potent against influenza A/Wyoming/03/03 (H3N2) and influenza A/California/04/2009 (H1N1) viruses, yielding IC50s of 0.12 μM and 0.2 μM, respectively.
M4 inhibits nuclear export of the vRNP complex, does not inhibit viral entry.
M4 demonstrates in vivo antiviral activity and enhances the efficacy of baloxavir in a mouse model of influenza A virus infection.

物理化学性质&存储条件

分子量	385.31
分子式	C18H12FN3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-(2-fluoro-5-nitrobenzamido)-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

参考文献

1. Sharma S, et al. PLoS Pathog. 2026 Sep 11;22(9):e1013914.