STA-2842 | HSP90 inhibitor HSP90 inhibitor Probechem Biochemicals

Chemical Structure : STA-2842

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STA-2842 (STA2842)

货号: PC-70347Not For Human Use, Lab Use Only.

STA-2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90.

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生物&药学活性

STA-2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90.
STA-2842 induces the degradation of many ADPKD-relevant HSP90 client proteins in Pkd1(-/-) primary kidney cells and in vivo.
STA-2842 significantly reduces initial formation of renal cysts and kidney growth and slows the progression of these phenotypes in mice with preexisting cysts.

物理化学性质&存储条件

分子量	550.66
分子式	C29H38N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2,4-dihydroxy-5-isopropylphenyl)-N-(2-morpholinoethyl)-4-(4-(morpholinomethyl)phenyl)-4H-1,2,4-triazole-3-carboxamide

参考文献

1. Seeger-Nukpezah T, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91.

2. Nikonova AS, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64.

3. Smithline ZB, et al. PLoS One. 2014 Dec 4;9(12):e114403.

STA-2842 (STA2842)

生物&药学活性

物理化学性质&存储条件

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STA-2842 (STA2842)

生物&药学活性

物理化学性质&存储条件

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