ST1936 oxalate | 5-HT6 agonist | Probechem Biochemicals

Chemical Structure : ST1936 oxalate

CAS No.: 1782228-83-4

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ST1936 oxalate (ST 1936)

货号: PC-73301Not For Human Use, Lab Use Only.

ST1936 oxalate is a potent, selective 5-HT6 receptor agonist with Ki of 13 nM, >10-fold selectivity over 5-HT7 and 5-HT2B receptors.

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10 mg	￥2180	In stock
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生物&药学活性

ST1936 oxalate is a potent, selective 5-HT6 receptor agonist with Ki of 13 nM, >10-fold selectivity over 5-HT7 and 5-HT2B receptors.
ST1936 displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM).
ST1936 was shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.
ST1936 reduced the frequency of spontaneous excitatory postsynaptic currents with IC50 of 1.3 uM, inhibited corticostriatal glutamatergic transmission.

物理化学性质&存储条件

分子量	326.777
分子式	C15H19ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindole oxalate

参考文献

1. Riccioni T, et al. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14.

2. Borsini F, et al. J Psychopharmacol. 2015 Jul;29(7):802-11.

3. Tassone A, et al. Neuropharmacology. 2011 Sep;61(4):632-7.

ST1936 oxalate (ST 1936)

生物&药学活性

物理化学性质&存储条件

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ST1936 oxalate (ST 1936)

生物&药学活性

物理化学性质&存储条件

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