ST171 (ST-171)

Chemical Structure : ST171

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货号: PC-28376Not For Human Use, Lab Use Only.

ST171 (ST-171) is a potent, functionally selective agonist of 5-HT1A receptor (5-HT1AR) with Ki of 0.41 nM, has 680-fold subtype selectivity over 5-HT2AR and 8000-fold selectivity over 5-HT6R, selectively activates 5-HT1AR-mediated Gi/o signaling.

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生物&药学活性

ST171 (ST-171) is a potent, functionally selective agonist of 5-HT1A receptor (5-HT1AR) with Ki of 0.41 nM, has 680-fold subtype selectivity over 5-HT2AR and 8000-fold selectivity over 5-HT6R, selectively activates 5-HT1AR-mediated Gi/o signaling.
ST171 inhibits cAMP accumulation with high efficacy and subnanomolar potency (EC50=0.88 nM).
ST171 functional selectivity for Gi/o over Gs, does not stimulate the recruitment of β-arrestin 1 or 2 to the 5-HT1AR.
ST171 also displays only moderate affinity, e.g., for the opioid receptor family (Ki > 5 μM) and α2A adrenergic receptors (Ki = 260 nM) in a set of 23 other class A GPCRs.
ST171 (10-20 mg/kg) reduces hypersensitivity in mouse models of chronic neuropathic and inflammatory pain.

物理化学性质&存储条件

分子量	372.42
分子式	C20H24N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(3-((2-(2-methoxyphenoxy)ethyl)amino)propoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one

参考文献

1. Ullrich A, et al. Sci Adv. 2025 Jun 20;11(25):eadv9267.

ST171 (ST-171)

生物&药学活性

物理化学性质&存储条件

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ST171 (ST-171)

生物&药学活性

物理化学性质&存储条件

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