ST-5-002

Chemical Structure : ST-5-002

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货号: PC-24008Not For Human Use, Lab Use Only.

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生物&药学活性

ST-5-002 is a specific small molecule inhibitor of transmembrane 4 L six family member 5 (TM4SF5), inhibits signaling lymphocytic activation molecule family member 7 (SLAMF7) degradation due to TM4SF5 binding and lysosomal translocation.
ST-5-002 reduces colocalization of TM4SF5 and SLAMF7 at lysosomes, leaving more SLAMF7 at the plasma membrane, recovers TM4SF5-dependent decrease in SLAMF7.
TM4SF5 bound SLAMF7 depending on N-glycosylation and caused intracellular trafficking of SLAMF7 from the plasma membrane to lysosomes for degradation.
ST-5-002 inhibits SLAMF7 degradation due to TM4SF5 binding and lysosomal translocation.
ST-5-002 (5 mpk, i.p.) recovered SLAMF7-positive cell populations to block cellular growth.
ST-5-002 abrogates HCC development by increasing the abundance and dispersion of Slamf7-positive cells in liver tissues, recapitulating the phenotype of Tm4sf5-knockout mice and indicating TSI-mediated restoration of NK cell surveillance.

物理化学性质&存储条件

分子量	370.41
分子式	C23H18N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-(4-Hydroxyphenyl)isoxazol-5-yl)phenyl)-4-methylbenzamide

参考文献

1. Kim JE, et al. Signal Transduct Target Ther. 2025 Jan 20;10(1):15.

ST-5-002

生物&药学活性

物理化学性质&存储条件

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ST-5-002

生物&药学活性

物理化学性质&存储条件

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