ST-168 |CAS:2126038-25-1 Probechem Biochemicals

Chemical Structure : ST-168

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ST-168 (ST168)

货号: PC-61741Not For Human Use, Lab Use Only.

ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.

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生物&药学活性

ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.
ST-168 exhibits improved inhibition toward PI3K isoforms compared to ST-162.
ST-168 demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model.

物理化学性质&存储条件

分子量	1010.762
分子式	C41H44F5IN10O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(2-(3-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

参考文献

1. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813.

ST-168 (ST168)

生物&药学活性

物理化学性质&存储条件

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ST-168 (ST168)

生物&药学活性

物理化学性质&存储条件

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