ST-162 |CAS:1883817-83-1 Probechem Biochemicals

Chemical Structure : ST-162

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ST-162 (ST162)

货号: PC-61742Not For Human Use, Lab Use Only.

ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.

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生物&药学活性

ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.
ST-162 produces regression of mutant KRAS or BRAF addicted xenograft models of colorectal cancer and melanoma and stasis of BRAF/PTEN mutant melanomas.
ST-162 increases efficacy in a syngeneic KRAS mutant colorectal cancer model combined with checkpoint blocker PD-L1.

物理化学性质&存储条件

分子量	982.752
分子式	C40H44F5IN10O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(2-(2-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

参考文献

1. Galbán S, et al. Mol Cancer Ther. 2017 Nov;16(11):2340-2350.

2. Van Dort ME, et al. J Med Chem. 2016 Mar 24;59(6):2512-22.

3. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813.

ST-162 (ST162)

生物&药学活性

物理化学性质&存储条件

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ST-162 (ST162)

生物&药学活性

物理化学性质&存储条件

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