ST-148 |CAS:400863-77-6 Probechem Biochemicals

Chemical Structure : ST-148

CAS No.: 400863-77-6

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ST-148 (ST148)

货号: PC-35008Not For Human Use, Lab Use Only.

ST-148 is a potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV capsid protein.

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5 mg	￥3480	In stock
10 mg	￥5280	In stock
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100 mg		Get quote

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生物&药学活性

ST-148 is a potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV capsid protein.
ST-148 exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively.
ST-148 significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice.

物理化学性质&存储条件

分子量	421.537
分子式	C21H19N5OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Amino-6,7,8,9-tetrahydro-5H-1-thia-10-aza-cyclohepta[f]indene-2-carboxylic acid (5-phenyl-[1,3,4]thiadiazol-2-yl)-amide

参考文献

1. Byrd CM, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):15-25.

2. Scaturro P, et al. J Virol. 2014 Oct;88(19):11540-55.

ST-148 (ST148)

生物&药学活性

物理化学性质&存储条件

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ST-148 (ST148)

生物&药学活性

物理化学性质&存储条件

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