ST-115 | Aminopeptidase P2 inhibitor | Probechem Biochemicals

Chemical Structure : ST-115

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ST-115 (ST115)

货号: PC-72623Not For Human Use, Lab Use Only.

ST-115 (ST115) is a potent and specific inhibitor of aminopeptidase P2 ((XPNPEP2, APP2) with IC50 of 3.7 nM.

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生物&药学活性

ST-115 (ST115) is a potent and specific inhibitor of aminopeptidase P2 (XPNPEP2, APP2) with IC50 of 3.7 nM.
ST-115 does not inhibit ACE, neprilysin, or multiple other enzymes, and littile inhibition against Aminopeptidase P1/A/B/N (IC50=600 nM->10 uM).
ST-115 can reduce bradykinin degradation, increasing its concentration and protective effects when administered intravenously at the start of reperfusion, reduced damaged area of the heart in a mouse model of myocardial infarction.
In a rat model of ischemic stroke, ST-115 reduced functional deficits in a skilled walking test by 60% and reduced brain edema by 51%.
ST-115 also reduced brain infarct size by 48% in a major subset of rats with small strokes.

物理化学性质&存储条件

分子量	457.561
分子式	C21H32FN3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(((2S,4S)-4-fluoro-1-((S)-2-mercapto-4-methylpentanoyl)pyrrolidine-2-carbonyl)-L-prolyl)pyrrolidine-3-carboxylic acid

参考文献

1. Morgan Rae Lenz, et al. J Pharmacol Exp Ther. 2022 Jan 3;JPET-AR-2021-000875.

ST-115 (ST115)

生物&药学活性

物理化学性质&存储条件

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ST-115 (ST115)

生物&药学活性

物理化学性质&存储条件

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