SSYA 10-001 | SARS-CoV-2 Nsp13 inhibitor | Probechem Biochemicals

Chemical Structure : SSYA 10-001

CAS No.: 675104-49-1

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SSYA 10-001 (DSHS00884, SSYA10-001)

货号: PC-72800Not For Human Use, Lab Use Only.

SSYA 10-001 (DSHS00884, SSYA10-001) is a small molecule inhibitor of SARS-CoV-2 Nsp13 helicase with IC50 of 3.5 uM.

规格	价格	库存
5 mg	￥2780	In stock
10 mg	￥4580	In stock
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100 mg		Get quote

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生物&药学活性

SSYA 10-001 (DSHS00884, SSYA10-001) is a small molecule inhibitor of SARS-CoV-2 Nsp13 helicase with IC50 of 3.5 uM.
SSYA 10-001 specifically blocks the double-stranded RNA (dsRNA) and dsDNA unwinding activities of nsp13 with IC50 of 5.70 and 5.30 uM, respectively.
SSYA 10-001 also has inhibitory activity (50% effective concentration [EC(50)] = 8.95 μM) in a SARS-CoV replicon assay, with low cytotoxicity.
SSYA10-001 does not affect ATP hydrolysis or nsp13 binding to the nucleic acid substrate.
SSYA10-001 did not inhibit hepatitis C virus (HCV) helicase, other bacterial and viral RNA-dependent RNA polymerases, or reverse transcriptase.
SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV).

物理化学性质&存储条件

分子量	308.37
分子式	C12H12N4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione

参考文献

1. Adedeji AO, et al. Antimicrob Agents Chemother. 2012 Sep;56(9):4718-28.

2. Adedeji AO, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4894-8.

SSYA 10-001 (DSHS00884, SSYA10-001)

生物&药学活性

物理化学性质&存储条件

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SSYA 10-001 (DSHS00884, SSYA10-001)

生物&药学活性

物理化学性质&存储条件

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