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首页-小分子抑制剂&激动剂-Others-Other Targets-SST0872AA1
SST0872AA1

Chemical Structure : SST0872AA1

CAS No.: 2245200-10-4

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SST0872AA1 (SST 0872AA1)

货号: PC-73270Not For Human Use, Lab Use Only.

SST0872AA1 is a potent, small molecule Heparanase (Hpse) inhibitor with IC50 of 0.08 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SST0872AA1 is a potent, small molecule Heparanase (Hpse) inhibitor with IC50 of 0.08 uM.
    SST0872AA1 inhibits the invasive ability of human CME-1 synovial sarcoma cells, does not affect cell proliferation.
    SST0872AA1 decreases the mRNA levels of genes encoding for proangiogenic factors, such as FGF1/2, VEGF, and MMP-9, and for Hpse (HPSE-1).

    物理化学性质&存储条件

    分子量 728.684
    分子式 C35H26F2N6O8S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,2'-((2,2'-(((Thiocarbonylbis(azanediyl))bis(3-fluoro-4,1-phenylene))bis(benzo[d]oxazole-2,5-diyl))bis(acetyl))bis(azanediyl))diacetic Acid

    参考文献

    1. Antonella Messore, et al. J Med Chem. 2018 Dec 13;61(23):10834-10859.

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