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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-FAAH-SSR411298
SSR411298

Chemical Structure : SSR411298

CAS No.: 666860-59-9

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SSR411298 (SSR-411298)

货号: PC-62533Not For Human Use, Lab Use Only.

SSR411298 is a highly selective, brain penetrant and orally-active inhibitor of FAAH with IC50 of 62.5 nM (mouse brain FAAH).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SSR411298 is a highly selective, brain penetrant and orally-active inhibitor of FAAH with IC50 of 62.5 nM (mouse brain FAAH).
    SSR411298 potently increases hippocampal levels of AEA, OEA and PEA in mice.
    SSR411298 produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress models.

    物理化学性质&存储条件

    分子量 402.447
    分子式 C21H26N2O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-amino-2-oxoethyl (3-((2r,5r)-5-(6-methoxynaphthalen-1-yl)-1,3-dioxan-2-yl)propyl)carbamate

    参考文献

    1. Griebel G, et al. Sci Rep. 2018 Feb 5;8(1):2416.

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