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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-SSR128129E
SSR128129E

Chemical Structure : SSR128129E

CAS No.: 848318-25-2

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SSR128129E (SSR 128129E)

货号: PC-22684Not For Human Use, Lab Use Only.

SSR128129E is a specific, allosteric, small-molecule multi-FGF receptor (FGFR) inhibitor, binds to the extracellular FGFR domain without affecting orthosteric FGF binding.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SSR128129E is a specific, allosteric, small-molecule multi-FGF receptor (FGFR) inhibitor, binds to the extracellular FGFR domain without affecting orthosteric FGF binding, inhibits FGF-induced signaling linked to FGFR internalization in an allosteric manner.
SSR128129E potently inhibits FGF2-induced endothelial cells (ECs) proliferation and migration with IC50 of 31 nM and 15.2 nM respectively.
SSR128129E inhibits FGFR paralogues in various species across the animal kingdom, including Danio rerio (zebrafish), Drosophila melanogaster (fruit fly), Spodoptera frugiperda , and Bombyx mori (silkworm).
SSR128129E does not inhibit binding of VEGF, VEGF-B, placental growth factor, platelet-derived growth factor (PDGF)-BB, or PDGF-CC.
SSR128129E inhibits tumor growth and metastasis in various models, amplifies the activity of anti-VEGFR2 in refractory tumor models.

物理化学性质&存储条件

分子量 346.32
分子式 C18H15N2NaO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Sodium 2-amino-5-(1-methoxy-2-methylindolizine-3-carbonyl)benzoate

参考文献

1. Bono F, et al. Cancer Cell. 2013 Apr 15;23(4):477-88.

2. Herbert C, et al. Cancer Cell. 2013 Apr 15;23(4):489-501.

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