SS-4 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : SS-4

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SS-4 (STAT3 inhibitor SS-4)

货号: PC-72849Not For Human Use, Lab Use Only.

SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.

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生物&药学活性

SS-4 (STAT3 inhibitor SS-4) is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.
SS-4 strongly and selectively inhibits STAT3 Y-705 phosphorylation in MT330 and LN229 GBM cells and inhibits their proliferation and inducs apoptosis with an IC50 of 100 nM.
SS-4 increases the expression of STAT3 repressed genes, while decreasing the expression of STAT3 promoted genes.
SS-4 markedly reduces the growth of GBM intracranial tumor xenografts.

物理化学性质&存储条件

分子量	348.42
分子式	C20H16N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-benzyl-3-cyanothiophen-2-yl)-2-phenoxyacetamide

参考文献

1. Yinan Wang, et al. Cancer Lett. 2022 Mar 1;533:215614.

SS-4 (STAT3 inhibitor SS-4)

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物理化学性质&存储条件

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SS-4 (STAT3 inhibitor SS-4)

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物理化学性质&存储条件

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