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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-SRX3212
SRX3212

Chemical Structure : SRX3212

CAS No.: 2735720-80-4

SRX3212 (SRX 3212)

货号: PC-73382Not For Human Use, Lab Use Only.

SRX3212 (SRX 3212) is a potent, dual BRD4/PI3Kα inhibitor with IC50 of 3.7 nM (BRD4 BD1) and 32 nM (BRD4 BD2), IC50 of 22 nM for PI3Kα.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SRX3212 (SRX 3212) is a potent, dual BRD4/PI3Kα inhibitor with IC50 of 3.7 nM (BRD4 BD1) and 32 nM (BRD4 BD2), IC50 of 22 nM for PI3Kα.
    SRX3212 demonstrated strong anti-cancer activity in cyclinD1 dependent mantle cell lymphoma cell lines (Jeko-1, Mino and Z138), a colon carcinoma cell line (HCT116), a MYCN amplified p53 mutated neuroblastoma cell line (SKNBE2) and a PTEN mutated prostate cancer cell line (PC3), with nanomolar to low micromolar IC50 values.

    物理化学性质&存储条件

    分子量 505.545
    分子式 C26H23N3O6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    7-(5-Morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)-N-(pyridin-3-ylmethyl)-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide

    参考文献

    1. Kendra R Vann, et al. Sci Rep. 2020 Jul 21;10(1):12027.

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