SRX3177 | BRD4/PI3K/CDK4/6 inhibitor | Probechem Biochemicals

Chemical Structure : SRX3177

CAS No.: 2241237-51-2

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SRX3177 (SRX 3177)

货号: PC-73383Not For Human Use, Lab Use Only.

SRX3177 is a potent, triple BRD4/PI3K/CDK4/6 inhibitor with nanomolar potency against PI3Kα (IC50=79 nM), BRD4 bromodomains (BD1 and BD2) (IC50=33 nM and 89 nM, respectively), and CDK4/6 (IC50=2.5/3.3 nM).

规格	价格	库存
1 mg	￥1380	In stock
5 mg	￥2980	In stock
10 mg	￥4880	In stock
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100 mg		Get quote

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生物&药学活性

SRX3177 is a potent, triple BRD4/PI3K/CDK4/6 inhibitor with nanomolar potency against PI3Kα (IC50=79 nM), BRD4 bromodomains (BD1 and BD2) (IC50=33 nM and 89 nM, respectively), and CDK4/6 (IC50=2.5/3.3 nM).
SRX3177 is capable of targeting BRD4, PI3K and CDK4/6 simultaneously, induces apoptosis and cell cycle arrest and has in vitro efficacy in mantle cell lymphoma, hepatocellular carcinoma and neuroblastoma models.
SRX3177 has antitumor efficacy in in vivo xenograft models and is less toxic than the combination of agents that inhibit individual targets.

物理化学性质&存储条件

分子量	584.695
分子式	C31H32N6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Cyclopentyl-N,N-dimethyl-2-((4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

参考文献

1. Kendra R Vann, et al. Sci Rep. 2020 Jul 21;10(1):12027.

2. Adam M Burgoyne, et al. Cell Discov. 2020 Jul 28;6(1):49.

SRX3177 (SRX 3177)

生物&药学活性

物理化学性质&存储条件

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SRX3177 (SRX 3177)

生物&药学活性

物理化学性质&存储条件

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