SRSF10 inhibitor 1C8 | SRSF10 inhibitor | Probechem Biochemicals

Chemical Structure : SRSF10 inhibitor 1C8

CAS No.: 1821309-39-0

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SRSF10 inhibitor 1C8 (HIV-1 inhibitor-6)

货号: PC-23021Not For Human Use, Lab Use Only.

SRSF10 inhibitor 1C8 is a specific small molecule inhibitor of SRSF1, alters splicing regulation mediated by SRSF10, shows strong anti-HIV-1 potency against a variety of clinical strains in vitro.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

SRSF10 inhibitor 1C8 is a specific small molecule inhibitor of SRSF1, alters splicing regulation mediated by SRSF10, shows strong anti-HIV-1 potency against a variety of clinical strains in vitro.
SRSF10 inhibitor 1C8 decreases expression of Tat, Gag and Env, similar with RNA interference.
SRSF10 inhibitor 1C8 selectively promotes the dephosphorylation of SRSF10 and increases its interaction with hTra2β, a protein previously implicated in the control of HIV-1 RNA splicing.
SRSF10 inhibitor 1C8 inhibited the expression of HCC tumor in vivo.

物理化学性质&存储条件

分子量	330.32
分子式	C14H10N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-N-(5-nitrobenzo[d]isothiazol-3-yl)-4-oxo-1,4-dihydropyridine-3-carboxamide

参考文献

1. Jialiang Cai, et al. Cancer Commun (Lond). 2024 Sep 2. doi: 10.1002/cac2.12607.

2. Shkreta L, et al. Nucleic Acids Res. 2017; 45(7): 4051-67.

3. Cheung P.K., et al. J. Med. Chem. 2016; 59:1869–1879.

SRSF10 inhibitor 1C8 (HIV-1 inhibitor-6)

生物&药学活性

物理化学性质&存储条件

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SRSF10 inhibitor 1C8 (HIV-1 inhibitor-6)

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物理化学性质&存储条件

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