SRS11-92 |CAS:1467047-25-1 Probechem Biochemicals

Chemical Structure : SRS11-92

CAS No.: 1467047-25-1

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SRS11-92 (SRS 11-92)

货号: PC-35991Not For Human Use, Lab Use Only.

SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.

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10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg	￥4380	In stock
100 mg		Get quote

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生物&药学活性

SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.
SRS11-92 inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2 uM.
SRS11-92 fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM.
SRS11-92 also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease in a concentration-dependent manner.

物理化学性质&存储条件

分子量	352.478
分子式	C22H28N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(cyclohexylamino)-3-[(phenylmethyl)amino]-benzoic acid, ethyl ester

参考文献

1. Cotticelli MG, et al. J Pharmacol Exp Ther. 2019 Jan 11. pii: jpet.118.252759.

2. Linkermann A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41.

SRS11-92 (SRS 11-92)

生物&药学活性

物理化学性质&存储条件

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SRS11-92 (SRS 11-92)

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物理化学性质&存储条件

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