SRPKIN-1 (JH-XI-05-01)

Chemical Structure : SRPKIN-1

CAS No.: 2089226-94-6

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货号: PC-63234Not For Human Use, Lab Use Only.

SRPKIN-1 (JH-XI-05-01) is a potent, selective, covalent SRPK1/2 inhibitor with IC50 of 35.6/98 nM, respectively.

规格	价格	库存
5 mg	￥2980	In stock
10 mg	￥4680	In stock
25 mg	￥7880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SRPKIN-1 (JH-XI-05-01) is a potent, selective, covalent SRPK1/2 inhibitor with IC50 of 35.6/98 nM, respectively.
SRPKIN-1 significantly attenuates SR protein phosphorylation in HeLa cells at 200 nM, switches VEGF splicing to produce the VEGF-A165b isoform (at 100 nM), converts the pro-angiogenic VEGF-A165a to the anti-angiogenic VEGF-A165b isoform, therefore functioning as an antagonist for VEGF-A165a to block angiogenesis.
SRPKIN-1 blocks laser-induced neovascularization in a murine retinal model.

物理化学性质&存储条件

分子量	472.534
分子式	C27H21FN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)benzenesulfonyl fluoride

参考文献

1. Hatcher JM, et al. Cell Chem Biol. 2018 Feb 14. pii: S2451-9456(18)30035-7.