SRPK1 inhibitor DBS1 | SRPK1 inhibitor | Probechem Biochemicals

Chemical Structure : SRPK1 inhibitor DBS1

加入收藏

SRPK1 inhibitor DBS1 (Docking Blocker of SRPK1)

货号: PC-49774Not For Human Use, Lab Use Only.

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SRPK1 inhibitor DBS1 (Docking Blocker of SRPK1) is a 20-mer peptide, cell-penetrating, non-ATP-competitive inhibitor of SRPK1 with ITC Kd of 5.6 uM, inhibits kinase activity of SRPK1 in a competitive manner against the substrate SRSF1 (Ki=2.12 uM), but not ATP.
DBS1 inhibited both SRPKs but not CLK1 or Akt/PKB, confirming it specifically targets the SRPK docking groove.
DBS1 inhibited SR protein phosphorylation in treated cells, switches the VEGF pre-mRNA splicing from VEGF165 to VEGF165b dose-dependently.
DBS1 is noncytotoxic to HUVECs and could potently inhibit angiogenesis.
Cotreatment of DBS1 with ATP-competitive inhibitor of SRPK1 (SRPIN340) inhibits angiogenesis more effectively.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Li Q, et al. iScience. 2021 Apr 20;24(5):102423.

SRPK1 inhibitor DBS1 (Docking Blocker of SRPK1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SRPK1 inhibitor DBS1 (Docking Blocker of SRPK1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.