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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-SRPK-SRPIN803
SRPIN803

Chemical Structure : SRPIN803

CAS No.: 380572-02-1

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SRPIN803 (SRPIN-803)

货号: PC-60568Not For Human Use, Lab Use Only.

SRPIN803 is a novel small molecule dual inhibitor of SRPK1 and CK2 with IC50 of 2.4 uM and 0.2 uM, respectively, does not inhibit SRPK2.

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5 mg ￥1480 In stock
10 mg ￥2280 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SRPIN803 is a novel small molecule dual inhibitor of SRPK1 and CK2 with IC50 of 2.4 uM and 0.2 uM, respectively, does not inhibit SRPK2.
SRPIN803 prevents VEGF production more effectively than SRPIN340, topical administration of SRPIN803 suppresses intraocular neovascularization in mouse model.

物理化学性质&存储条件

分子量 370.306
分子式 C14H9F3N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,6-Dihydro-6-[(4-hydroxy-3-methoxyphenyl)methylene]-5-imino-2-(trifluoromethyl)-7H-1,3,4-thiadiazolo[3,2-a]pyrimidin-7-one

参考文献

1. Morooka S, et al. Mol Pharmacol. 2015 Aug;88(2):316-25.

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