欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-SRPK-SRPIN340
SRPIN340

Chemical Structure : SRPIN340

CAS No.: 218156-96-8

加入收藏

SRPIN340 (SRPIN 340)

货号: PC-49772Not For Human Use, Lab Use Only.

SRPIN340 (SRPIN 340) is a potent, highly selective inhibitor of serine-arginine-rich protein kinase (SRPK1) with Ki value of 0.89 uM (SRPK1).

规格 价格 库存 数量
5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SRPIN340 (SRPIN 340) is a potent, highly selective inhibitor of serine-arginine-rich protein kinase (SRPK1) with Ki value of 0.89 uM (SRPK1).
SRPIN340 does not significantly inhibit other SRPK, such as Clk1 and Clk4, as well as any additional Ser/Thr kinases.
SRPIN340 is highly specific for both kinases SRPK1 and SRPK2.
SRPIN340 inhibits SR phosphorylation by SRPK in Flp-In293 cells and promotes degradation of SRp75 in a dose-dependent manner.
SRPIN340 (40 μM) rescues Vero cells from the cytopathic effect of Sindbis virus, with IC50 of 60 uM for Sindbis virus propagation.
SRPIN340 suppressed in a dose-dependent fashion expression of a HCV subgenomic replicon and replication of the HCV-JFH1 clone in vitro.
SRPIN340 also shows significant cytotoxic activity on lymphoid and myeloid leukemia cell lines, triggers early and late events of apoptosis.

物理化学性质&存储条件

分子量 349.36
分子式 C18H18F3N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide

参考文献

1. Fukuhara T, et al. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11329-33.

2. Siqueira RP, et al. PLoS One. 2015 Aug 5;10(8):e0134882.

3. Karakama Y, et al. Antimicrob Agents Chemother. 2010 Aug;54(8):3179-86.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: